An Optimal Control of Bone Marrow in Cancer Chemotherapy by Artificial Neural Networks

H. Hosseinipour, H. R. Sahebi

Abstract


Although neural network models for cancer chemotherapy have been analyzed since the early seventies, less research has been done in actually formulating them as optimal control problems. In this paper an artificial neural networks-based method for optimal control of bone marrow in cell-cycle-specific chemotherapy is proposed. In this method, we use artificial neural networks for approximating the optimal control problem which maximizes both bone marrow mass and drug`s dose at the same time. The corresponding model be transfer to Hamiltonian function and using Pontryagin principle we create the boundary conditions. After defining boundary conditions, we use the approximating property of artificial networks and put the boundary conditions in error functions to satisfy the limitations..

Keywords


Optimal control; Bone marrow; Cancer chemotherapy; Artificial neural networks

Full Text:

PDF


Lululemon Black Friday cheap nfl jerseys Lululemon factory Outlet ny Black Friday discount tiffany outlet wholesale soccer jerseys online oakley black friday cheap nhl jerseys china cheap nfl jerseys north face black friday sale cheap nfl jerseys online Jordans Black Friday Sale 2015 Cheap Moncler Cyber Monday moncler outlet cheap soccer jerseys moncler outlet black friday cheap authentic nfl jerseys north face cyber monday Louboutin Black Friday canada wholesale cheap nfl jerseys lululemon cyber monday 2015 cheap nfl jerseys from china 2015 Cheap Moncler Black Friday Sale Moncler Cyber Monday 2015 cheap jerseys Lululemon Cyber Monday Sale jordans cyber monday deals 2015 cheap nike nfl jerseys Black Friday deals Lululemon 2015 jordan black friday 2015 Moncler Jackets Black Friday Sale 2015 Louboutin Pas Cher Black Friday 2015 Canada Lululemon north face black friday cheap wholesale soccer jerseys